High barrier packaging materials for most gunpowde

2022-09-23
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Pharmaceutical high barrier packaging materials

in the outline of the Tenth Five Year Plan for the development of pharmaceutical packaging industry in China, it is clearly pointed out that the overall level of pharmaceutical packaging in China still lags behind developed countries, and the quality of pharmaceutical packaging materials and the contribution rate of packaging to the pharmaceutical economy are lower than the international level. The proportion of packaging and drug value in developed countries is 15% - 20%, and some are as high as 30%; In China, it only accounts for 8% to 9%. The drug packaging, which accounts for about 65% of the total amount of preparations, has not reached the average level of the 1980s

the pharmaceutical industry is showing a trend of rapid internationalization and enterprise resource integration, and this trend will continue to develop. In the process of resource integration, enterprises expect to reduce costs, optimize the use of production equipment, reduce indirect costs, and improve the process of quickly bringing products to market. The result of its development is to promote the development of more professional, scientific, simple and reasonable packaging, processes and strategies

the State Food and drug administration is vigorously promoting the registration and management of drugs and drug packaging materials, in line with international practices, improving the international competitiveness of domestic drugs, and putting an end to the phenomenon that the same patented drugs have different names. Therefore, we must choose the right packaging materials, and enough to protect drugs. These packaging materials are not necessarily the same as the original packaging materials, because during the service life of these drugs, the materials may not be fully utilized by the API manufacturing company, and the high barrier performance of drug packaging is the most important criterion to be considered. It is the sacred mission of Jiangsu Qionghua High Tech Co., Ltd. to change the backward status of pharmaceutical packaging, adopt new technology and develop pharmaceutical high barrier packaging materials

high barrier materials are mainly divided into three types, namely PVDC, ev-oh and pan (polyethylene terephthalate). The three materials are copolymers, and the barrier property to oxygen, ev-oh is better than PVDC, PVDC is better than pan; For the barrier of water vapor, ev-oh is better than PVDC, and PVDC is better than pan. However, under high humidity conditions, the barrier performance of ev-oh decreases significantly. At the same time, with the increase of environmental humidity, the barrier property of Pan materials also decreased significantly. In terms of comprehensive performance, PVDC material is the best

pvdc is polyvinylidene chloride, which has two states, one is light yellow, powdered resin, and the other is latex like opaque liquid. PVDC powder resin can be extruded and blown by adding certain stabilizers and plasticizers. The product is mainly used for the packaging of casing film; PVDC latex is mainly coated on the surface of PVC, pet and other sheets or films. The products are mainly used in pharmaceutical blister packaging, granular powder packaging and food packaging

in addition to the general properties of plastics, high barrier composites coated with PVDC latex also have self extinguishing, oil resistance, fragrance retention, excellent moisture and mold resistance, as well as excellent printing and heat sealing properties. They are the best comprehensive barrier among many plastic packaging materials. It is not only different from ev-oh (polyvinyl alcohol) which decreases the barrier performance significantly with the increase of humidity, but also different from pan which deteriorates the barrier performance due to water absorption. It is a high barrier material with excellent moisture and gas resistance, and the environmental conditions have little influence on its barrier performance

new processing technology of PVDC coated composites

PVDC (polyvinylidene chloride) is difficult to process. Although it has excellent barrier properties, it cannot be industrialized. Therefore, the commonly called PVDC refers to the copolymerized polymer material with vinylidene chloride (VDC) as the main body. The VDC content of PVDC used in packaging industry is about 90%, and the commonly used monomers are acrylic acid, acrylate, etc. These copolymers played an internal plasticizing role, improved the processability of PVDC, and did not cause a fatal reduction in its barrier performance

pvdc processing industry began in the late 1930s and was first realized by Dow Chemical Company of the United States. At that time, it coincided with the "World War II", and PVDC was mainly used for military packaging. Later, with the rapid development of world industry, especially the food processing industry, PVDC showed extremely excellent performance in the preservation of non frozen food, the quality assurance of food and drugs, and the extension of shelf life. For decades, PVDC, as a high barrier packaging material, has always been in a leading position, although there are also ev-oh and pan materials, However, their high barrier performance has decreased significantly in high humidity environment and has not been further developed. Similarly, PA (not a strictly defined barrier material) can not replace the excellent high barrier function of PVDC for the packaging protection of contents, and the usual practice also needs to improve its packaging performance by using PVDC coating process

pvdc latex coating process flow is different from PVDC resin blowing and extrusion process. PVDC latex coating process flow:

substrate unwinding → pretreatment → primer → IR and air drying → intermediate coating → IR and air drying → surface coating → IR and air drying → reeling. From coated 10 It can be seen from the belt loosening process that drives the oil pump that the coating of latex only involves coating and heating and drying. There is no additional additive in the final film formation, so although the coating has only μ M thick, but its barrier performance to oxygen and wet steam is equivalent to 25 μ The barrier property of M blown film Among them, primer, IR and air drying are the proprietary new technologies of Qionghua high tech

as a pharmaceutical high barrier packaging material, PVDC coated composite material is most suitable for making blister packaging of drugs and composite packaging bags of granules and powders, because the mechanical and some specific physical properties of the coating material are determined by the coated substrate, and the final permeability, fragrance retention and oil resistance are provided by the coating, Users only need to determine the mechanical and physical performance requirements of the packaging materials and the degree of protection according to the characteristics of the packaged contents and the circulation environment to select the barrier ability of the substrate and coating. The base material for blister packaging is PVC sheet, and the base material for composite packaging bags of granules and powders is BOPET or BOPP film

the barrier ability of PVDC coating is not only directly related to the thickness of the coating, but also related to the film-forming process and process control of the coating. During the film-forming process of PVDC latex coating, it is necessary to ensure that all coatings are fully dry; Ensure sufficient heat energy supply and exchange to make water volatilize at a uniform speed; In particular, the drying of the primer must be carried out through the proprietary IR and air drying technology of Qionghua High Tech Institute, so as to ensure that there is no excessive drying. After the coating pinholes or surface crusts appear due to the boiling of waterproof parts, the bottom water vapor penetrates, resulting in the cracking of the coating or the insufficient drying of the inner layer. During the drying process, it should be ensured that there is sufficient air velocity and exchange capacity (generally 50000 m3/h) to purge the water film on the surface of the coating, so that there is a reasonable water gradient distribution from the interior of the coating to the surface of the wire rod changing the operating procedures of the testing machine, so that the water can migrate to the surface quickly. There is a reasonable drying time (at least 7 seconds) in the drying process of the surface coating, so that the PVDC coating can be further oriented and the molecules can fully move, the crystallinity can be improved, the higher the crystallinity is, the better the barrier performance is, and the low molecular weight polymer monomer in the PVDC copolymer can be evaporated as much as possible. These are conducive to improving the barrier performance of PVDC coating, ensuring that PVDC has good solvent resistance and effectively reducing the residual solvent in the process of printing and composite processing; Qionghua high tech uses water-soluble materials, so there is no solvent residue problem, and it can effectively ensure the peel strength of the coating. The national drug packaging container (material) standard YBB of the state drug administration stipulates that the peel strength is 6.0n/15mm. Qionghua high tech adopts proprietary technology, which makes the peel strength greater than 10n/15mm, and also improves the gloss and transparency of the coated composite materials

The drying and film forming process of PVDC is not so simple. How to fully understand this process and design a more reasonable process control process? After five years of practice and exploration, Jiangsu Qionghua High Tech Co., Ltd. finally explored a scientific and reasonable new coating composite processing technology. Only with scientific and reasonable process design and accurate process control, can we produce high-quality PVDC coating composites and reflect the true face of PVDC, a high barrier pharmaceutical packaging material. It is not easy to reflect this. Therefore, there is no quality guarantee to realize PVDC emulsion coating production on dry compounding machine or printing machine. It can only provide limited barrier performance, and is likely to bring other quality problems. Such as poor oil and solvent resistance, insufficient composite peel strength, etc. In addition, we cannot scribe the coating surface as flat as the horizontal plane. From the microscopic point of view, any surface has a roughness. At present, it is not difficult to find products with coarser coatings in the domestic market. Rough coating (even coating streamline or cracking) not only brings uneven ink splashing transfer defects to printing, but also defects such as thick coating, insufficient drying, insufficient coating density, insufficient barrier ability, weak solvent resistance and low composite peel strength at the peak of roughness. Strictly speaking, this is not a qualified PVDC coated composite product

how to effectively combine the equipment structure, latex formula, tension setting, speed control, temperature control and other aspects is the core technical secret of PVDC coating manufacturers. Qionghua high tech has a number of proprietary new technologies in this field, ensuring the leading technology and excellent quality of products. In short, PVDC coated composite is a barrier packaging material that has been proved by more than 30 years of use in developed countries. At present, there is no substitute for materials with better value and function. In Japan, the vast majority of blister packaging uses PVC packaging coated with PVDC (according to Ichi Osaka, director of Toray Institute of chemistry in Japan). In Germany, 80% of drug blister packaging uses pvc/pvdc high barrier packaging materials, while in China, the proportion of blister packaging using this material is less than 5%. At present, the key is how to better understand and master the performance and reasonable processing process of PVDC. To objectively show its true appearance. Actively guide domestic pharmaceutical companies to understand and use the material

packaging demand is determined by the characteristics of the contents of the packaging and the product circulation environment after packaging; The packaging of vitamin E capsules with PVC blisters will cause moisture absorption, deliquescence and even wall adhesion after a period of time. If PVC packaging coated with PVDC is used, this phenomenon can be avoided. If nylon/pe packaging is used to process meat products correctly according to the regulations, it is feasible to vacuum in northern China except in summer, but in summer due to humidity and heat, The barrier property of nylon decreases sharply, so that this composite structure can not meet the needs of processing meat products. Another example is bopp/pe, a composite film with simple structure, which is feasible for the outer packaging of instant noodles, but it is completely impossible to use the composite film with this structure for the packaging of biscuits and sweets. This is not only because its moisture and gas resistance is slightly insufficient, but more importantly, this composite film does not have fragrance retention ability at all. If the packaging of foods such as biscuits and candies is not sufficient, for example, the measurement range is the correct way to choose and buy the pressure testing machine: the fragrance retention and odor isolation ability of the material and specification of the sample will be greatly reduced. Drug granules

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